<- Home <- Arhive <- Vol. 25, Issue 4, December 2017

Rom J Leg Med25(4)331-336(2017)
© Romanian Society of Legal Medicine

Multidrug resistance stimulated antagonistic antibiotic interactions

K. Yilancioglu, O. Unlu

Abstract: Urinary tract infections (UTIs) are the most common bacterial infections caused by predominantly Escherichia coli. Increasing antimicrobial resistance and transmission among the strains cause a serious problem, which needs immediate consideration. Treatment options are narrowed and the success rate is decreasing because of the strong multi-drug-resistant pathogenic bacterial strains. Especially synergistic antimicrobial combination therapy is a rational option with potential benefits. However, some antibiotic combinations exhibit antagonistic interaction that hinders treatment efforts. Therefore, screening antibiotic combinations in terms of their interaction types prior to treatment is crucial. In this study, we aimed to screen the response of strong and intermediate multi-drug resistant (MDR) E. coli strains to several protein synthesis inhibitor antibiotic combinations. Experimented antibiotic combinations were found to be antagonistic along with a retrospective analysis among 20 more antibiotics of the same class demonstrated antagonistic interaction. Interestingly and most importantly, antagonism level is found to be associated with the level of drug resistance. This result suggests that stronger MDR pathogen exhibits stronger antagonistic interactions compared to the intermediate MDR strain when protein synthesis inhibitor antibiotics are combined. As a result, antibiotic combinations should be more carefully evaluated when multi-drug regimens are planned to be administered to severe infections to avoid antagonizing individual drug effectiveness.
Keywords: antibiotic, antagonism, drug interaction.

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